Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis.

Medve, Laura; Achilli, Silvia; Guzman-Caldentey, Joan; Thépaut, Michel; Senaldi, Luca; Le Roy, Aline; Sattin, Sara; Ebel, Christine; Vivès, Corinne; Martin-Santamaria, Sonsoles; Bernardi, Anna; Fieschi, Franck.

Afiliação

Medve L; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133, Milano, Italy.
Achilli S; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.
Guzman-Caldentey J; Department of Structural and Chemical Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040, Madrid, Spain.
Thépaut M; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.
Senaldi L; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133, Milano, Italy.
Le Roy A; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.
Sattin S; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133, Milano, Italy.
Ebel C; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.
Vivès C; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.
Martin-Santamaria S; Department of Structural and Chemical Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040, Madrid, Spain.
Bernardi A; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133, Milano, Italy.
Fieschi F; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38044, Grenoble, France.