Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk.

Harris, Kelly L; Myers, Meagan B; McKim, Karen L; Elespuru, Rosalie K; Parsons, Barbara L

Harris, Kelly L; Myers, Meagan B; McKim, Karen L; Elespuru, Rosalie K; Parsons, Barbara L.

Afiliação

Harris KL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.
Myers MB; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.
McKim KL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.
Elespuru RK; Division of Biology, Chemistry and Materials Science, CDRH/OSEL, US Food and Drug Administration, Silver Spring, Maryland.
Parsons BL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.

Environ Mol Mutagen ; 61(1): 152-175, 2020 01.

Article em En | MEDLINE | ID: mdl-31469467

Assuntos

Carcinogênese/genética; Mutação; Neoplasias/genética; Animais; Biomarcadores Tumorais/genética; Carcinogênese/induzido quimicamente; Carcinógenos/toxicidade; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Humanos; Mutação/efeitos dos fármacos; Neoplasias/induzido quimicamente; Medição de Risco/métodos

Palavras-chave

biomarker; cancer risk assessment; carcinogenesis; cell communication; cell signaling; mutation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinogênese / Mutação / Neoplasias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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