Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail <i>Nerita versicolor</i>.

Covaleda-Cortés, Giovanni; Hernández, Martha; Trejo, Sebastián Alejandro; Mansur, Manuel; Rodríguez-Calado, Sergi; García-Pardo, Javier; Lorenzo, Julia; Vendrell, Josep; Chávez, María Ángeles; Alonso-Del-Rivero, Maday; Avilés, Francesc Xavier

Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita versicolor.

Covaleda-Cortés, Giovanni; Hernández, Martha; Trejo, Sebastián Alejandro; Mansur, Manuel; Rodríguez-Calado, Sergi; García-Pardo, Javier; Lorenzo, Julia; Vendrell, Josep; Chávez, María Ángeles; Alonso-Del-Rivero, Maday; Avilés, Francesc Xavier.

Afiliação

Covaleda-Cortés G; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Hernández M; Faculty of Forestry Science, Biotechnology Center, Universidad de Concepción, Victoria 631, Barrio Universitario, 2407 Concepción, Chile.
Trejo SA; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Mansur M; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Rodríguez-Calado S; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
García-Pardo J; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Lorenzo J; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. Julia.Lorenzo@uab.cat.
Vendrell J; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Chávez MÁ; Center for Protein Research, Faculty of Biology, Universidad de la Habana, 10400 La Habana, Cuba.
Alonso-Del-Rivero M; Center for Protein Research, Faculty of Biology, Universidad de la Habana, 10400 La Habana, Cuba. maday@fbio.uh.cu.
Avilés FX; Institute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. FrancescXavier.Aviles@uab.es.

Mar Drugs ; 17(9)2019 Aug 29.

Article em En | MEDLINE | ID: mdl-31470614

Assuntos

Organismos Aquáticos/química; Proteínas/antagonistas & inibidores; Caramujos/química; Sequência de Aminoácidos; Animais; Sequência de Bases; Sítios de Ligação; Clonagem Molecular/métodos; DNA Complementar/metabolismo; Humanos; Especificidade por Substrato

Palavras-chave

Nerita versicolor; biotechnological and biomedical applications; carboxypeptidase; picomolar inhibition; proteinaceous inhibitor; recombinant production

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caramujos / Proteínas / Organismos Aquáticos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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