Terasaki spiral ramps and intracellular diffusion.
Phys Biol
; 16(6): 065002, 2019 10 10.
Article
em En
| MEDLINE
| ID: mdl-31476742
ABSTRACT
The sheet-like endoplasmic reticulum (ER) of eukaryotic cells has been found to be riddled with spiral dislocations, known as 'Terasaki ramps', in the vicinity of which the doubled bilayer membranes which make up ER sheets can be approximately modeled by helicoids. Here we analyze diffusion on a surface with locally helicoidal topological dislocations, and use the results to argue that the Terasaki ramps facilitate a highly efficient transport of water-soluble molecules both within the lumen of the endoplasmic reticulum, and in the adjacent cytoplasmic space.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retículo Endoplasmático
/
Células Eucarióticas
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article