Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages.

Cirone, Karina M; Lahiri, Priyoshi; Holani, Ravi; Tan, Yi Lin; Arrazuria, Rakel; De Buck, Jeroen; Barkema, Herman W; Cobo, Eduardo R

Cirone, Karina M; Lahiri, Priyoshi; Holani, Ravi; Tan, Yi Lin; Arrazuria, Rakel; De Buck, Jeroen; Barkema, Herman W; Cobo, Eduardo R.

Afiliação

Cirone KM; Department of Animal Production, National Agricultural Technology Institute, Buenos Aires, Argentina.
Lahiri P; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Holani R; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Tan YL; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Arrazuria R; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
De Buck J; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Barkema HW; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Cobo ER; Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada. ecobo@ucalgary.ca.

Cell Tissue Res ; 379(1): 207-217, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31478135

Assuntos

Antibacterianos/farmacologia; Peptídeos Catiônicos Antimicrobianos/farmacologia; Citocinas/metabolismo; Macrófagos/microbiologia; Mycobacterium avium subsp. paratuberculosis/efeitos dos fármacos; Paratuberculose/microbiologia; Animais; Antibacterianos/síntese química; Peptídeos Catiônicos Antimicrobianos/síntese química; Bovinos; Linhagem Celular; Citocinas/genética; Expressão Gênica/efeitos dos fármacos; Humanos; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Camundongos; Mycobacterium avium subsp. paratuberculosis/isolamento & purificação; Paratuberculose/tratamento farmacológico; Paratuberculose/imunologia; Catelicidinas

Palavras-chave

Cathelicidin; IL-8; LL-37; Macrophages; Mycobacterium avium subsp. paratuberculosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paratuberculose / Citocinas / Mycobacterium avium subsp. paratuberculosis / Peptídeos Catiônicos Antimicrobianos / Macrófagos / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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