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Decreased humoral immunity to mumps in young adults immunized with MMR vaccine in childhood.
Rasheed, Mohammed Ata Ur; Hickman, Carole J; McGrew, Marcia; Sowers, Sun Bae; Mercader, Sara; Hopkins, Amy; Grimes, Vickie; Yu, Tianwei; Wrammert, Jens; Mulligan, Mark J; Bellini, William J; Rota, Paul A; Orenstein, Walter A; Ahmed, Rafi; Edupuganti, Srilatha.
Afiliação
  • Rasheed MAU; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322.
  • Hickman CJ; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
  • McGrew M; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Sowers SB; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Mercader S; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Hopkins A; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Grimes V; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Yu T; Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30030.
  • Wrammert J; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322.
  • Mulligan MJ; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322.
  • Bellini WJ; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
  • Rota PA; Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30030.
  • Orenstein WA; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Ahmed R; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329.
  • Edupuganti S; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322.
Proc Natl Acad Sci U S A ; 116(38): 19071-19076, 2019 09 17.
Article em En | MEDLINE | ID: mdl-31481612
In the past decade, multiple mumps outbreaks have occurred in the United States, primarily in close-contact, high-density settings such as colleges, with a high attack rate among young adults, many of whom had the recommended 2 doses of mumps-measles-rubella (MMR) vaccine. Waning humoral immunity and the circulation of divergent wild-type mumps strains have been proposed as contributing factors to mumps resurgence. Blood samples from 71 healthy 18- to 23-year-old college students living in a non-outbreak area were assayed for antibodies and memory B cells (MBCs) to mumps, measles, and rubella. Seroprevalence rates of mumps, measles, and rubella determined by IgG enzyme-linked immunosorbent assay (ELISA) were 93, 93, and 100%, respectively. The index standard ratio indicated that the concentration of IgG was significantly lower for mumps than rubella. High IgG avidity to mumps Enders strain was detected in sera of 59/71 participants who had sufficient IgG levels. The frequency of circulating mumps-specific MBCs was 5 to 10 times lower than measles and rubella, and 10% of the participants had no detectable MBCs to mumps. Geometric mean neutralizing antibody titers (GMTs) by plaque reduction neutralization to the predominant circulating wild-type mumps strain (genotype G) were 6-fold lower than the GMTs against the Jeryl Lynn vaccine strain (genotype A). The majority of the participants (80%) received their second MMR vaccine ≥10 years prior to study participation. Additional efforts are needed to fully characterize B and T cell immune responses to mumps vaccine and to develop strategies to improve the quality and durability of vaccine-induced immunity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacina contra Sarampo-Caxumba-Rubéola / Anticorpos Neutralizantes / Imunidade Humoral / Anticorpos Antivirais / Caxumba / Vírus da Caxumba Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacina contra Sarampo-Caxumba-Rubéola / Anticorpos Neutralizantes / Imunidade Humoral / Anticorpos Antivirais / Caxumba / Vírus da Caxumba Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article