Your browser doesn't support javascript.
loading
Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a.
Tahara, Tomomitsu; Tahara, Sayumi; Horiguchi, Noriyuki; Kawamura, Tomohiko; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Urano, Makoto; Tsukamoto, Tetsuya; Kuroda, Makoto; Ohmiya, Naoki.
Afiliação
  • Tahara T; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Tahara S; Department of Diagnostic Pathology I, School of Medicine, Fujita Health University , Toyoake , Japan.
  • Horiguchi N; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Kawamura T; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Okubo M; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Nagasaka M; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Nakagawa Y; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Shibata T; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
  • Urano M; Department of Diagnostic Pathology I, School of Medicine, Fujita Health University , Toyoake , Japan.
  • Tsukamoto T; Department of Diagnostic Pathology I, School of Medicine, Fujita Health University , Toyoake , Japan.
  • Kuroda M; Department of Diagnostic Pathology I, School of Medicine, Fujita Health University , Toyoake , Japan.
  • Ohmiya N; Department of Gastroenterology, Fujita Health University School of Medicine , Toyoake , Japan.
Cancer Invest ; 37(9): 417-426, 2019.
Article em En | MEDLINE | ID: mdl-31483161
ABSTRACT
To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Regulação para Baixo / Infecções por Helicobacter / MicroRNAs / Imagem de Banda Estreita / Mucosa Gástrica Tipo de estudo: Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Regulação para Baixo / Infecções por Helicobacter / MicroRNAs / Imagem de Banda Estreita / Mucosa Gástrica Tipo de estudo: Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article