Are social inequalities in acute myeloid leukemia survival explained by differences in treatment utilization? Results from a French longitudinal observational study among older patients.
BMC Cancer
; 19(1): 883, 2019 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-31488077
ABSTRACT
BACKGROUND:
Evidences support social inequalities in cancer survival. Studies on hematological malignancies, and more specifically Acute Myeloid Leukemia (AML), are sparser. Our study assessed 1/ the influence of patients' socioeconomic position on survival, 2/ the role of treatment in this relationship, and 3/ the influence of patients' socioeconomic position on treatment utilization.METHODS:
This prospective multicenter study includes all patients aged 60 and older, newly diagnosed with AML, excluding promyelocytic subtypes, between 1st January 2009 to 31st December 2014 in the South-West of France. Data came from medical files. Patients' socioeconomic position was measured by an ecological deprivation index, the European Deprivation Index. We studied first, patients' socioeconomic position influence on overall survival (n = 592), second, on the use of intensive chemotherapy (n = 592), and third, on the use of low intensive treatment versus best supportive care among patients judged unfit for intensive chemotherapy (n = 405).RESULTS:
We found an influence of patients' socioeconomic position on survival (highest versus lowest position HRQ5 1.39 [1.05;1.87] that was downsized to become no more significant after adjustment for AML ontogeny (HRQ5 1.31[0.97;1.76] and cytogenetic prognosis HRQ5 1.30[0.97;1.75]). The treatment was strongly associated with survival. A lower proportion of intensive chemotherapy was observed among patients with lowest socioeconomic position (ORQ5 0.41[0.19;0.90]) which did not persist after adjustment for AML ontogeny (ORQ5 0.59[0.25;1.40]). No such influence of patients' socioeconomic position was found on the treatment allocation among patients judged unfit for intensive chemotherapy.CONCLUSIONS:
Finally, these results suggest an indirect influence of patients' socioeconomic position on survival through AML initial presentation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fatores Socioeconômicos
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Leucemia Mieloide Aguda
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Aceitação pelo Paciente de Cuidados de Saúde
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Protocolos de Quimioterapia Combinada Antineoplásica
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Disparidades em Assistência à Saúde
/
Sobreviventes de Câncer
Tipo de estudo:
Clinical_trials
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
/
Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article