mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.

Beaumatin, Florian; O'Prey, Jim; Barthet, Valentin J A; Zunino, Barbara; Parvy, Jean-Philippe; Bachmann, Alexis Maximilien; O'Prey, Margaret; Kania, Elzbieta; Gonzalez, Pablo Sierra; Macintosh, Robin; Lao, Laurence Y; Nixon, Colin; Lopez, Jonathan; Long, Jaclyn S; Tait, Stephen W G; Ryan, Kevin M

Beaumatin, Florian; O'Prey, Jim; Barthet, Valentin J A; Zunino, Barbara; Parvy, Jean-Philippe; Bachmann, Alexis Maximilien; O'Prey, Margaret; Kania, Elzbieta; Gonzalez, Pablo Sierra; Macintosh, Robin; Lao, Laurence Y; Nixon, Colin; Lopez, Jonathan; Long, Jaclyn S; Tait, Stephen W G; Ryan, Kevin M.

Afiliação

Beaumatin F; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
O'Prey J; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Barthet VJA; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Zunino B; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Parvy JP; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Bachmann AM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
O'Prey M; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Kania E; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Gonzalez PS; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Macintosh R; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Lao LY; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Nixon C; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Lopez J; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Long JS; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Tait SWG; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Ryan KM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.ryan@beatson.gla.ac.uk.

Mol Cell ; 76(1): 163-176.e8, 2019 10 03.

Article em En | MEDLINE | ID: mdl-31492633

Assuntos

Aminoácidos/metabolismo; Proteína 7 Relacionada à Autofagia/metabolismo; Metabolismo Energético; Lisossomos/enzimologia; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Proteínas de Membrana/metabolismo; Células 3T3-L1; Adipócitos/enzimologia; Adipogenia; Sistema ASC de Transporte de Aminoácidos/genética; Sistema ASC de Transporte de Aminoácidos/metabolismo; Sistema y+L de Transporte de Aminoácidos/genética; Sistema y+L de Transporte de Aminoácidos/metabolismo; Animais; Proteína 7 Relacionada à Autofagia/genética; Glicemia/metabolismo; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Ativação Enzimática; Células HEK293; Células HeLa; Humanos; Insulina/sangue; Transportador 1 de Aminoácidos Neutros Grandes/genética; Transportador 1 de Aminoácidos Neutros Grandes/metabolismo; Masculino; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Proteínas de Membrana/deficiência; Proteínas de Membrana/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Antígenos de Histocompatibilidade Menor/genética; Antígenos de Histocompatibilidade Menor/metabolismo; Transporte Proteico

Palavras-chave

DRAM-1; SCAMP3; amino acid transporters; and adipocyte differentiation; autophagy; insulin signaling; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metabolismo Energético / Proteína 7 Relacionada à Autofagia / Alvo Mecanístico do Complexo 1 de Rapamicina / Aminoácidos / Lisossomos / Proteínas de Membrana Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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