How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice.
Cells
; 8(9)2019 09 07.
Article
em En
| MEDLINE
| ID: mdl-31500247
ABSTRACT
Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage sensing and repair is integral to survival but is largely thought to occur primarily in interphase and be repressed during mitosis due to the risk of telomere fusion. There is, however, increasing evidence to suggest tight control of mitotic progression in the incidence of DNA damage, whether induced in mitotic cells or having progressed from failed interphase checkpoints. Here we will discuss what is known to date about signaling pathways controlling mitotic progression and resulting cell fate in the incidence of mitotic DNA damage.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Quebras de DNA
/
Mitose
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article