Development of Treatments for Localized Prostate Cancer in Patients Eligible for Active Surveillance: U.S. Food and Drug Administration Oncology Center of Excellence Public Workshop.
J Urol
; 203(1): 115-119, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31502940
ABSTRACT
PURPOSE:
The following is a summary of discussion at a United States FDA (Food and Drug Administration) public workshop reviewing potential trial designs and end points to develop therapies to treat localized prostate cancer. MATERIALS ANDMETHODS:
The workshop focused on the challenge that drug and device development to treat localized prostate cancer has been limited by the large trial sizes and lengthy timelines required to demonstrate an improvement in overall or metastasis-free survival and by the lack of agreed on alternative end points. Additionally, evolving treatment paradigms in the management of localized prostate cancer include the widespread use of active surveillance of patients with low and some intermediate risk prostate cancer, and the availability of advances in imaging and genomics.RESULTS:
The workshop addressed issues related to trial design in this setting. Attendees discussed several potential novel end points such as a delay of morbidity due to radiation or prostatectomy and pathological end points such as Gleason Grade Group upgrade.CONCLUSIONS:
The workshop provided an open forum for multiple stakeholder engagement to advance the development of effective treatment options for men with localized prostate cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Projetos de Pesquisa
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United States Food and Drug Administration
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Ensaios Clínicos como Assunto
Tipo de estudo:
Diagnostic_studies
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Screening_studies
Limite:
Humans
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Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article