A Novel DNA Helical Wire Containing HgII -Mediated T:T and T:G Pairs.
Angew Chem Int Ed Engl
; 58(47): 16835-16838, 2019 11 18.
Article
em En
| MEDLINE
| ID: mdl-31507027
ABSTRACT
Numerous applications of metal-mediated base pairs (metallo-base-pairs) to nucleic acid based nanodevices and genetic code expansion have been extensively studied. Many of these metallo-base-pairs are formed in DNA and RNA duplexes containing Watson-Crick base pairs. Recently, a crystal structure of a metal-DNA nanowire with an uninterrupted one-dimensional silver array was reported. We now report the crystal structure of a novel DNA helical wire containing HgII -mediated TT and TG base pairs and water-mediated CC base pairs. The Hg-DNA wire does not contain any Watson-Crick base pairs. Crystals of the Hg-DNA wire, which is the first DNA wire structure driven by HgII ions, were obtained by mixing the short oligonucleotide d(TTTGC) and HgII ions. This study demonstrates the potential of metallo-DNA to form various structural components that can be used for functional nanodevices.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timina
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DNA
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Nanofios
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Guanina
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Mercúrio
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article