Enhanced molecular typing and macrolide and tetracycline-resistance mutations of Treponema pallidum in Barcelona.
Future Microbiol
; 14: 1099-1108, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31512516
ABSTRACT
Aim:
To describe the molecular types of Treponema pallidum and the proportion of macrolide and tetracycline resistance mutations in Barcelona. Materials &methods:
Molecular type was determined using the Enhanced-CDC Typing system and antibiotic resistance was determined by sequencing the 23S and 16S rRNA genes.Results:
A total of 183 patients were enrolled and 213 specimens (99 ulcers, 114 bloods) were collected. Sixty-two (70.5%) of 88 ulcers and 0 (0%) of bloods T. pallidum-DNA containing samples were fully typed. Up to 21 different strain types were identified (14d/g in 27.4%; 14f/g in 14.5%). Macrolide resistance mutations were present in 95% and tetracycline in 0%.Conclusion:
Several different strains co-exist in Barcelona with a high proportion of macrolide resistance and absence of tetracycline resistance.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tetraciclina
/
Treponema pallidum
/
Sífilis
/
Macrolídeos
/
Farmacorresistência Bacteriana
/
Tipagem Molecular
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article