Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).

Hussein, Buthaina; Ikhmais, Balqis; Kadirvel, Manikandan; Magwaza, Rachael N; Halbert, Gavin; Bryce, Richard A; Stratford, Ian J; Freeman, Sally

Hussein, Buthaina; Ikhmais, Balqis; Kadirvel, Manikandan; Magwaza, Rachael N; Halbert, Gavin; Bryce, Richard A; Stratford, Ian J; Freeman, Sally.

Afiliação

Hussein B; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK.
Ikhmais B; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK.
Kadirvel M; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK.
Magwaza RN; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK.
Halbert G; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0NR, UK.
Bryce RA; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK.
Stratford IJ; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK. Electronic address: Ian.J.Stratford@manchester.ac.uk.
Freeman S; Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK. Electronic address: Sally.Freeman@manchester.ac.uk.

Eur J Med Chem ; 182: 111649, 2019 Nov 15.

Article em En | MEDLINE | ID: mdl-31514018

Assuntos

Aminoquinolinas/farmacologia; Descoberta de Drogas; Inibidores Enzimáticos/farmacologia; Hidrazonas/farmacologia; Quinona Redutases/antagonistas & inibidores; Aminoquinolinas/síntese química; Aminoquinolinas/química; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Humanos; Hidrazonas/síntese química; Hidrazonas/química; Modelos Moleculares; Estrutura Molecular; Quinona Redutases/metabolismo; Relação Estrutura-Atividade; Células Tumorais Cultivadas

Palavras-chave

4-Aminoquinoline; Anticancer; CB1954; Hydrazine; NQO2 inhibitors; Ovarian cancer; SKOV-3â¯cells; TOV-112D cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinona Redutases / Inibidores Enzimáticos / Descoberta de Drogas / Aminoquinolinas / Hidrazonas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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