Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients.
Int J Mol Sci
; 20(18)2019 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-31514293
ABSTRACT
BACKGROUND:
Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides.METHODS:
Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted.RESULTS:
Analyzing the association between ceramides level and MIB-1, total ceramides and dihydroceramides showed a strong association (r = 0.7257 and r = 0.6733, respectively) with MIB-1 staining (p = 0.0033 and p = 0.0083, respectively). Among the single ceramide species, Cer C241 (r = 0.8814, p ≤ 0.0001), DHCer C241 (r = 0.8429, p = 0.0002) and DHCer C180 (r = 0.9426, p ≤ 0.0001) showed a significant correlation with MIB-1.CONCLUSION:
Our lipid analysis showed ceramides to be promising tumoral biomarkers in skull base chordomas. Long- and very-long-chain ceramides, such as Cer C241 and DHCer C241, may be related to a prolonged tumor survival and aggressiveness, and the understanding of their effective biological role will hopefully shed light on the mechanisms of chordoma radio-resistance, tendency to recur, and use of agents targeting ceramide metabolism.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cordoma
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Ceramidas
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Neoplasias da Base do Crânio
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Agressão
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article