Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells.
Mol Cell Oncol
; 6(5): e1536843, 2019.
Article
em En
| MEDLINE
| ID: mdl-31528687
ABSTRACT
Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article