Combination treatment in metastatic castration-resistant prostate cancer: can we safely boost efficacy by adding radium-223?
Cancer Biol Ther
; 21(1): 1-3, 2020.
Article
em En
| MEDLINE
| ID: mdl-31530074
ABSTRACT
ERA 223, a phase III, international, multicenter, double-blind study published in Lancet Oncology, was the first randomized controlled trial to investigate combined radium-223 (Ra-223) and abiraterone acetate plus prednisone or prednisolone (AAP) therapy. The data from ERA 223 demonstrated no increase in efficacy for this combination over AAP alone, and instead identified a significant safety concern due to the higher risk of fracture in the co-treatment group. The surprising results of this trial likely stem from the compounding osteoporotic effects of the different treatments, particularly the addition of prednisone, and supplementing therapy regimens with osteoprotective agents may aid in mitigating this safety risk.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rádio (Elemento)
/
Neoplasias de Próstata Resistentes à Castração
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article