Hybrid material for open abdomen: saving the wound from intestinal fistula.
J Mater Sci Mater Med
; 30(9): 109, 2019 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-31535210
ABSTRACT
Treatment of an open abdomen (OA) wound combined with an intestinal fistula is a challenge in the clinic. Here, inspired by the antibacterial activity of graphene (G) and its derivatives, we present a hybrid patch based on the ability of graphene and polycaprolactone (PCL) to kill bacteria and save the cells in a wound. Benefiting from the antibacterial ability of graphene oxide (GO), cells could survive in the presence of bacteria. With the increased ability to protect cells, this patch accelerated wound healing in an OA and intestinal fistula wound model. Additionally, the sub-acute toxicity score showed no extra damage to organs. In conclusion, the employment of the hybrid material for an OA and an intestinal fistula wound healing is encouraging. A hybrid patch based on graphene oxide and polycaprolactone electrospun was generated for open abdomen and fistula wound. The application of the hybrid patch could save the cells from bacteria which contribute to accelerating wound healing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Telas Cirúrgicas
/
Cicatrização
/
Fístula Intestinal
/
Técnicas de Abdome Aberto
/
Grafite
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article