The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.
Blood
; 134(22): 1941-1950, 2019 11 28.
Article
em En
| MEDLINE
| ID: mdl-31537530
Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG) exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires between different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, which are characterized by the common loss of Galα and GalNAc reactivity and disease-specific recognition of microbial antigens, self-antigens, and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the degree and the clinical implications of immune system failure in individual patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
/
Imunoglobulina G
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Carboidratos
/
Doenças da Imunodeficiência Primária
/
Epitopos
Tipo de estudo:
Qualitative_research
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article