Mechanical stretch promotes tumoricidal M1 polarization <i>via</i> the FAK/NF-&#954;B signaling pathway.

Shan, Shengzhou; Fang, Bin; Zhang, Yifan; Wang, Chuandong; Zhou, Jia; Niu, Chenguang; Gao, Ya; Zhao, Danyang; He, Jiahao; Wang, Jing; Zhang, Xiaoling; Li, Qingfeng

Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway.

Shan, Shengzhou; Fang, Bin; Zhang, Yifan; Wang, Chuandong; Zhou, Jia; Niu, Chenguang; Gao, Ya; Zhao, Danyang; He, Jiahao; Wang, Jing; Zhang, Xiaoling; Li, Qingfeng.

Afiliação

Shan S; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fang B; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang C; Department of Orthopedic Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhou J; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Niu C; Department of Endodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gao Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao D; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
He J; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang J; Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhang X; Department of Orthopedic Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Q; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

FASEB J ; 33(12): 13254-13266, 2019 12.

Article em En | MEDLINE | ID: mdl-31539281

Assuntos

Proteína-Tirosina Quinases de Adesão Focal/metabolismo; NF-kappa B/metabolismo; Transdução de Sinais/fisiologia; Animais; Western Blotting; Citocinas/metabolismo; Feminino; Proteína-Tirosina Quinases de Adesão Focal/genética; Marcação In Situ das Extremidades Cortadas; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/genética; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Células RAW 264.7; Reação em Cadeia da Polimerase em Tempo Real; Transdução de Sinais/genética

Palavras-chave

cancer; focal adhesion kinase; immunotherapy; macrophage polarization; mechanical force

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Proteína-Tirosina Quinases de Adesão Focal Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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