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Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders.
Bawari, Sweta; Tewari, Devesh; Argüelles, Sandro; Sah, Archana N; Nabavi, Seyed Fazel; Xu, Suowen; Vacca, Rosa Anna; Nabavi, Seyed Mohammad; Shirooie, Samira.
Afiliação
  • Bawari S; School of Pharmacy, Sharda University, Knowledge Park-III, Greater Noida, Uttar Pradesh, 201310, India.
  • Tewari D; Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India. Electronic address: dtewari3@gmail.com.
  • Argüelles S; Department of Physiology, University of Seville, Spain.
  • Sah AN; Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand 263136, India.
  • Nabavi SF; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Xu S; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  • Vacca RA; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Via Amendola 165/A, I-70126, Bari, Italy.
  • Nabavi SM; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
  • Shirooie S; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, 6734667149, Kermanshah, Iran.
Pharmacol Res ; 148: 104458, 2019 10.
Article em En | MEDLINE | ID: mdl-31546015
Neurodegenerative disorders like Alzheimer's disease, Huntington's disease, Parkinson's disease, spinocerebellar ataxias, amyotrophic lateral sclerosis, frontotemporal dementia to prion diseases, Friedreich's ataxia, hereditary spastic paraplegia and optic atrophy type 1, and behavior disorders like neuropsychiatric, hyperactivity and autism spectrum disorders are closely associated with neurobiological deficits. Brain derived neurotrophic factor (BDNF) is an extensively studied neurotrophin. BDNF is essential for neuronal genesis, differentiation, survival, growth, plasticity, synaptic viability and transmission. BDNF has emerged as a promising target for regulating synaptic activity and plasticity. An overview of effects and mechanisms of the natural products targeting BDNF is described. This review is an attempt to enumerate the effects of various natural products on BDNF as a novel therapeutic approach for neurodegenerative and neuropsychiatric disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Transdução de Sinais / Fator Neurotrófico Derivado do Encéfalo / Doenças Neurodegenerativas / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Transdução de Sinais / Fator Neurotrófico Derivado do Encéfalo / Doenças Neurodegenerativas / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article