Monitoring the topical delivery of ultrasmall gold nanoparticles using optical coherence tomography.
Skin Res Technol
; 26(2): 263-268, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31556193
ABSTRACT
BACKGROUND:
Optical coherence tomography (OCT) is a promising imaging modality for skin cancer diagnosis. However, this capability has been hindered by the low contrast between normal and neoplastic tissue. To overcome this limitation, gold nanoparticles have been used to enhance the contrast in OCT images and are topically administered to reduce the risk of systematic side effects associated with intravenous injection. To ensure efficient penetration and distribution of the nanoparticles, an enhanced delivery strategy is required. In this porcine study, we assessed two deliverymethods:
(a) using dimethyl sulfoxide (DMSO) and (b) via sonophoresis. MATERIALS ANDMETHODS:
The gold nanoparticles were topically applied on pig skin before evaluating DMSO and sonophoresis as penetration enhancers in topical administration. The OCT images were taken from the same locations to monitor signal change.CONCLUSION:
The combination of DMSO and sonophoresis is an effective method to enhance the penetration and diffusion rate of nanoparticles during topical administration.SIGNIFICANCE:
Topical administration of nanoparticles is advantageous in dermatological applications. Nevertheless, efficient topical delivery remains a challenge. DMSO and sonophoresis can be used as two effective approaches to enhance topical delivery of nanoparticles.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Sistemas de Liberação de Medicamentos
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Tomografia de Coerência Óptica
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Nanopartículas Metálicas
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Ouro
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article