Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children.
Medicine (Baltimore)
; 98(38): e17185, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31567961
ABSTRACT
Infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus (PVL-SA) mostly present as recurrent skin abscesses and furunculosis. However, life-threatening infections (eg, necrotizing pneumonia, necrotizing fasciitis, and osteomyelitis) caused by PVL-SA have also been reported.We assessed the clinical phenotype, frequency, clinical implications (surgery, length of treatment in hospitals/intensive care units, and antibiotic treatments), and potential preventability of severe PVL-SA infections in children.Total, 75 children treated for PVL-SA infections in our in- and outpatient units from 2012 to 2017 were included in this retrospective study.Ten out of 75 children contracted severe infections (PVL-methicillin resistant S aureus nâ=â4) including necrotizing pneumonia (nâ=â4), necrotizing fasciitis (nâ=â2), pyomyositis (nâ=â2; including 1 patient who also had pneumonia), mastoiditis with cerebellitis (nâ=â1), preorbital cellulitis (nâ=â1), and recurrent deep furunculosis in an immunosuppressed patient (nâ=â1). Specific complications of PVL-SA infections were venous thrombosis (nâ=â2), sepsis (nâ=â5), respiratory failure (nâ=â5), and acute respiratory distress syndrome (nâ=â3). The median duration of hospital stay was 14 days (range 5-52 days). In 6 out of 10 patients a history suggestive for PVL-SA colonization in the patient or close family members before hospital admission was identified.PVL-SA causes severe to life-threatening infections requiring lengthy treatments in hospital in a substantial percentage of symptomatic PVL-SA colonized children. More than 50% of severe infections might be prevented by prompt testing for PVL-SA in individuals with a history of abscesses or furunculosis, followed by decolonization measures.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
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Staphylococcus aureus
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Toxinas Bacterianas
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Exotoxinas
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Leucocidinas
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article