Nucleic acid-induced dimerization of HIV-1 Gag protein.

Zhao, Huaying; Datta, Siddhartha A K; Kim, Sung H; To, Samuel C; Chaturvedi, Sumit K; Rein, Alan; Schuck, Peter

Zhao, Huaying; Datta, Siddhartha A K; Kim, Sung H; To, Samuel C; Chaturvedi, Sumit K; Rein, Alan; Schuck, Peter.

Afiliação

Zhao H; Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892.
Datta SAK; HIV Dynamics and Replication Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702.
Kim SH; Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892.
To SC; Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892.
Chaturvedi SK; Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892.
Rein A; HIV Dynamics and Replication Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702.
Schuck P; Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892 peter.schuck@nih.gov.

J Biol Chem ; 294(45): 16480-16493, 2019 11 08.

Article em En | MEDLINE | ID: mdl-31570521

Assuntos

HIV-1/metabolismo; Oligonucleotídeos/metabolismo; Produtos do Gene gag do Vírus da Imunodeficiência Humana/metabolismo; Calorimetria; Dimerização; Humanos; Cinética; Oligonucleotídeos/química; Ligação Proteica; Domínios Proteicos; Espectrometria de Fluorescência; Termodinâmica; Produtos do Gene gag do Vírus da Imunodeficiência Humana/química

Palavras-chave

Gag multimerization; analytical ultracentrifugation; fluorescence; fluorescence-detected sedimentation velocity; human immunodeficiency virus (HIV); protein oligomerization; protein-nucleic acid interaction; virus assembly; virus-like particle (VLP)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / HIV-1 / Produtos do Gene gag do Vírus da Imunodeficiência Humana Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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