Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m<sup>6</sup>A abrogation in RNA.

Zhou, Peihui; Wu, Ming; Ye, Chaoyang; Xu, Qingqing; Wang, Li

Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m⁶A abrogation in RNA.

Zhou, Peihui; Wu, Ming; Ye, Chaoyang; Xu, Qingqing; Wang, Li.

Afiliação

Zhou P; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Wu M; Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Traditional Chinese Medicine Institute of Kidney Disease of Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai
Ye C; Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Traditional Chinese Medicine Institute of Kidney Disease of Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai
Xu Q; Department of Nephrology, Ningbo First Hospital Ningbo Hospital of Zhejiang University, Ningbo 315000, China.
Wang L; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China wlyjy73122@126.com.

J Biol Chem ; 294(45): 16908-16917, 2019 11 08.

Article em En | MEDLINE | ID: mdl-31578283

Assuntos

Injúria Renal Aguda/patologia; Tecido Adiposo/efeitos dos fármacos; Dioxigenase FTO Dependente de alfa-Cetoglutarato/metabolismo; Cisplatino/farmacologia; Ácido Meclofenâmico/farmacologia; RNA/química; RNA/metabolismo; Injúria Renal Aguda/induzido quimicamente; Injúria Renal Aguda/genética; Injúria Renal Aguda/metabolismo; Tecido Adiposo/metabolismo; Tecido Adiposo/patologia; Dioxigenase FTO Dependente de alfa-Cetoglutarato/deficiência; Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular; Sinergismo Farmacológico; Regulação da Expressão Gênica/efeitos dos fármacos; Técnicas de Silenciamento de Genes; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

Fat mass and obesity-associated protein, FTO; N6-methyladenosine, m6A; RNA methylation; RNA modification; acute kidney injury, AKI; apoptosis; caspase; cell signaling; cisplatin; kidney; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / Tecido Adiposo / Ácido Meclofenâmico / Cisplatino / Injúria Renal Aguda / Dioxigenase FTO Dependente de alfa-Cetoglutarato Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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