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Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes.
Spyrou, Maria A; Keller, Marcel; Tukhbatova, Rezeda I; Scheib, Christiana L; Nelson, Elizabeth A; Andrades Valtueña, Aida; Neumann, Gunnar U; Walker, Don; Alterauge, Amelie; Carty, Niamh; Cessford, Craig; Fetz, Hermann; Gourvennec, Michaël; Hartle, Robert; Henderson, Michael; von Heyking, Kristin; Inskip, Sarah A; Kacki, Sacha; Key, Felix M; Knox, Elizabeth L; Later, Christian; Maheshwari-Aplin, Prishita; Peters, Joris; Robb, John E; Schreiber, Jürgen; Kivisild, Toomas; Castex, Dominique; Lösch, Sandra; Harbeck, Michaela; Herbig, Alexander; Bos, Kirsten I; Krause, Johannes.
Afiliação
  • Spyrou MA; Max Planck Institute for the Science of Human History, 07745, Jena, Germany. spyrou@shh.mpg.de.
  • Keller M; Institute for Archaeological Sciences, University of Tübingen, 72070, Tübingen, Germany. spyrou@shh.mpg.de.
  • Tukhbatova RI; Max Planck Institute for the Science of Human History, 07745, Jena, Germany.
  • Scheib CL; SNSB, State Collection for Anthropology and Palaeoanatomy Munich, 80333, Munich, Germany.
  • Nelson EA; Max Planck Institute for the Science of Human History, 07745, Jena, Germany.
  • Andrades Valtueña A; Laboratory of Structural Biology, Kazan Federal University, Kazan, Russian Federation, 420008.
  • Neumann GU; Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Walker D; Max Planck Institute for the Science of Human History, 07745, Jena, Germany.
  • Alterauge A; Institute for Archaeological Sciences, University of Tübingen, 72070, Tübingen, Germany.
  • Carty N; Max Planck Institute for the Science of Human History, 07745, Jena, Germany.
  • Cessford C; Max Planck Institute for the Science of Human History, 07745, Jena, Germany.
  • Fetz H; MOLA (Museum of London Archaeology), London, N1 7ED, UK.
  • Gourvennec M; Department of Physical Anthropology, Institute for Forensic Medicine, University of Bern, 3007, Bern, Switzerland.
  • Hartle R; MOLA (Museum of London Archaeology), London, N1 7ED, UK.
  • Henderson M; Department of Archaeology, University of Cambridge, Downing St, Cambridge, CB2 3ER, UK.
  • von Heyking K; Archaeological Service, State Archive Nidwalden, 6371, Nidwalden, Switzerland.
  • Inskip SA; Archeodunum SAS, Agency Toulouse, 8 allée Michel de Montaigne, 31770, Colomiers, France.
  • Kacki S; MOLA (Museum of London Archaeology), London, N1 7ED, UK.
  • Key FM; MOLA (Museum of London Archaeology), London, N1 7ED, UK.
  • Knox EL; SNSB, State Collection for Anthropology and Palaeoanatomy Munich, 80333, Munich, Germany.
  • Later C; McDonald Institute for Archaeological Research, University of Cambridge, Downing St, Cambridge, CB2 3ER, UK.
  • Maheshwari-Aplin P; PACEA, CNRS Institute, Université de Bordeaux, 33615, Pessac, France.
  • Peters J; Department of Archaeology, Durham University, South Rd, Durham, DH1 3LE, UK.
  • Robb JE; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Schreiber J; MOLA (Museum of London Archaeology), London, N1 7ED, UK.
  • Kivisild T; Bavarian State Department of Monuments and Sites, 80539, Munich, Germany.
  • Castex D; Department of Archaeology, University of Cambridge, Downing St, Cambridge, CB2 3ER, UK.
  • Lösch S; SNSB, State Collection for Anthropology and Palaeoanatomy Munich, 80333, Munich, Germany.
  • Harbeck M; ArchaeoBioCenter and Department of Veterinary Sciences, Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, Ludwig Maximilian University Munich, Kaulbachstr. 37/III, 80539, Munich, Germany.
  • Herbig A; Department of Archaeology, University of Cambridge, Downing St, Cambridge, CB2 3ER, UK.
  • Bos KI; Dig it! Company GbR, 86971, Peiting, Germany.
  • Krause J; Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
Nat Commun ; 10(1): 4470, 2019 10 02.
Article em En | MEDLINE | ID: mdl-31578321
ABSTRACT
The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541-750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peste / Yersinia pestis / DNA Bacteriano / Genoma Bacteriano / Sequenciamento de Nucleotídeos em Larga Escala / Pandemias Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peste / Yersinia pestis / DNA Bacteriano / Genoma Bacteriano / Sequenciamento de Nucleotídeos em Larga Escala / Pandemias Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article