Synthetic ecology of the human gut microbiota.
Nat Rev Microbiol
; 17(12): 754-763, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31578461
ABSTRACT
Despite recent advances in sequencing and culturing, a deep knowledge of the wiring and functioning of the human gut ecosystem and its microbiota as a community is still missing. A holistic mechanistic understanding will require study of the gut microbiota as an interactive and spatially organized biological system, which is difficult to do in complex natural communities. Synthetic gut microbial ecosystems can function as model systems to further current understanding of the composition, stability and functional activities of the microbiota. In this Review, we provide an overview of the current synthetic ecology strategies that can be used towards a more comprehensive understanding of the human gut ecosystem. Such approaches that integrate in vitro experiments using cultured isolates with mathematical modelling will enable the ultimate goal translating mechanistic and ecological knowledge into novel and effective therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia Sintética
/
Microbiota
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Microbioma Gastrointestinal
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Interações entre Hospedeiro e Microrganismos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article