Inverse agonists of the 5-HT<sub>2A</sub> receptor reduce nicotine withdrawal signs in rats.

Malin, David; Henceroth, Mallori; Rao, Gadam Srinivas; Campbell, Joseph; Ma, Jian-Nong; Tsai, Ping-Hsun; Kishbaugh, Jordan C; Burstein, Ethan S

Inverse agonists of the 5-HT_2A receptor reduce nicotine withdrawal signs in rats.

Malin, David; Henceroth, Mallori; Rao, Gadam Srinivas; Campbell, Joseph; Ma, Jian-Nong; Tsai, Ping-Hsun; Kishbaugh, Jordan C; Burstein, Ethan S.

Afiliação

Malin D; University of Houston-Clear Lake, United States. Electronic address: orkidfam@swbell.net.
Henceroth M; University of Houston-Clear Lake, United States.
Rao GS; University of Houston-Clear Lake, United States.
Campbell J; University of Houston-Clear Lake, United States.
Ma JN; ACADIA Pharmaceuticals Inc., United States.
Tsai PH; University of Houston-Clear Lake, United States.
Kishbaugh JC; University of Houston-Clear Lake, United States.
Burstein ES; ACADIA Pharmaceuticals Inc., United States.

Neurosci Lett ; 713: 134524, 2019 11 20.

Article em En | MEDLINE | ID: mdl-31585211

Assuntos

Fluorbenzenos/farmacologia; Nicotina/efeitos adversos; Piperidinas/farmacologia; Receptor 5-HT2A de Serotonina/efeitos dos fármacos; Síndrome de Abstinência a Substâncias/prevenção & controle; Ureia/análogos & derivados; Animais; Relação Dose-Resposta a Droga; Agonismo Inverso de Drogas; Masculino; Ratos; Receptor 5-HT2C de Serotonina/efeitos dos fármacos; Antagonistas do Receptor 5-HT2 de Serotonina/farmacologia; Ureia/farmacologia

Palavras-chave

5-HT(2A)receptor; Nicotine dependence; Nicotine withdrawal; Pimavanserin; Volinanserin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Síndrome de Abstinência a Substâncias / Ureia / Receptor 5-HT2A de Serotonina / Fluorbenzenos / Nicotina Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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