IgM paraprotein-associated peripheral neuropathy: small CD20-positive B-cell clones may predict a monoclonal gammopathy of neurological significance and rituximab responsiveness.

Chen, Lucia Y; Keddie, Stephen; Lunn, Michael P; Bomsztyk, Joshua; Vitsaras, Evan; Gupta, Rajeev; D'Sa, Shirley

Chen, Lucia Y; Keddie, Stephen; Lunn, Michael P; Bomsztyk, Joshua; Vitsaras, Evan; Gupta, Rajeev; D'Sa, Shirley.

Afiliação

Chen LY; Cancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
Keddie S; MRC Centre for Neuromuscular Disease, National Hospital of Neurology and Neurosurgery and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Lunn MP; Neuroimmunology and CSF laboratory, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
Bomsztyk J; MRC Centre for Neuromuscular Disease, National Hospital of Neurology and Neurosurgery and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Vitsaras E; Neuroimmunology and CSF laboratory, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
Gupta R; Cancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
D'Sa S; Manual Blood Sciences, HSL Pathology, London, UK.

Br J Haematol ; 188(4): 511-515, 2020 02.

Article em En | MEDLINE | ID: mdl-31588566

Assuntos

Antígenos CD20/sangue; Linfócitos B/metabolismo; Imunoglobulina M/sangue; Paraproteinemias; Paraproteínas/metabolismo; Doenças do Sistema Nervoso Periférico; Rituximab/administração & dosagem; Idoso; Humanos; Masculino; Pessoa de Meia-Idade; Paraproteinemias/sangue; Paraproteinemias/tratamento farmacológico; Doenças do Sistema Nervoso Periférico/sangue; Doenças do Sistema Nervoso Periférico/tratamento farmacológico

Palavras-chave

MYD88; B cell; IgM; neuropathy; rituximab

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paraproteinemias / Imunoglobulina M / Paraproteínas / Linfócitos B / Doenças do Sistema Nervoso Periférico / Antígenos CD20 / Rituximab Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google