Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells.

Yu, Lan; Tian, Xin; Gao, Dexuan; Lang, Yue; Zhang, Xiang-Xiang; Yang, Chen; Gu, Meng-Meng; Shi, Jianming; Zhou, Ping-Kun; Shang, Zeng-Fu

Yu, Lan; Tian, Xin; Gao, Dexuan; Lang, Yue; Zhang, Xiang-Xiang; Yang, Chen; Gu, Meng-Meng; Shi, Jianming; Zhou, Ping-Kun; Shang, Zeng-Fu.

Afiliação

Yu L; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Tian X; Suzhou Digestive Diseases and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Gao D; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Lang Y; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Zhang XX; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Yang C; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Gu MM; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Shi J; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Zhou PK; Suzhou Digestive Diseases and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Shang ZF; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.

Nanotoxicology ; 13(10): 1409-1421, 2019 12.

Article em En | MEDLINE | ID: mdl-31589482

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Grafite/toxicidade; Mucosa Intestinal/efeitos dos fármacos; Pontos Quânticos/toxicidade; Células-Tronco/efeitos dos fármacos; Administração Oral; Animais; Apoptose/genética; Proliferação de Células/genética; Dano ao DNA; Grafite/química; Hidroxilação; Mucosa Intestinal/patologia; Intestino Delgado/efeitos dos fármacos; Intestino Delgado/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Estresse Oxidativo/efeitos dos fármacos; Permeabilidade; Pontos Quânticos/química; Células-Tronco/patologia; Propriedades de Superfície; Proteína Supressora de Tumor p53/genética

Palavras-chave

DNA damage; Graphene quantum dots; intestinal injury; intestinal stem cells; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Apoptose / Pontos Quânticos / Proliferação de Células / Grafite / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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