Detection of Candida auris antifungal drug resistance markers directly from clinical skin swabs.
Antimicrob Agents Chemother
; 63(12)2019 09 09.
Article
em En
| MEDLINE
| ID: mdl-31591112
ABSTRACT
Accurate and rapid assessment of Candida auris antifungal drug resistance is crucial for effective infection prevention and control actions, and patient management. Here, performance of a molecular diagnostic platform, enabling rapid identification of FKS1 and ERG11 mutations conferring echinocandin and azole resistance, respectively, was evaluated on a panel of clinical skin swabs. Gene sequencing and antifungal susceptibility testing were used as "gold standard". All swabs were correctly categorized as harboring wild-type or mutant C. auris.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article