miR-149-3p reverses CD8<sup>+</sup> T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells.

Zhang, Meng; Gao, Dian; Shi, Yanmei; Wang, Yifan; Joshi, Rakesh; Yu, Qiongfang; Liu, Daheng; Alotaibi, Faizah; Zhang, Yujuan; Wang, Hongmei; Li, Qing; Zhang, Zhu-Xu; Koropatnick, James; Min, Weiping

miR-149-3p reverses CD8⁺ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells.

Zhang, Meng; Gao, Dian; Shi, Yanmei; Wang, Yifan; Joshi, Rakesh; Yu, Qiongfang; Liu, Daheng; Alotaibi, Faizah; Zhang, Yujuan; Wang, Hongmei; Li, Qing; Zhang, Zhu-Xu; Koropatnick, James; Min, Weiping.

Afiliação

Zhang M; Institute of Immunotherapy of Nanchang University, and Jiangxi Academy of Medical Sciences, Nanchang 330006, People's Republic of China.
Gao D; Department of Surgery, Western University, London, Canada N6A 5A5.
Shi Y; Department of Pathology and Laboratory Medicine, Western University, London, Canada N6A 5A5.
Wang Y; Department of Oncology, Western University, London, Canada N6A 5A5.
Joshi R; Department of Microbiology and Immunology, Western University, London, Canada N6A 5A5.
Yu Q; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang 330006, People's Republic of China.
Liu D; Institute of Immunotherapy of Nanchang University, and Jiangxi Academy of Medical Sciences, Nanchang 330006, People's Republic of China.
Alotaibi F; Department of Surgery, Western University, London, Canada N6A 5A5.
Zhang Y; Department of Pathology and Laboratory Medicine, Western University, London, Canada N6A 5A5.
Wang H; Department of Oncology, Western University, London, Canada N6A 5A5.
Li Q; Department of Microbiology and Immunology, Western University, London, Canada N6A 5A5.
Zhang ZX; Department of Oncology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
Koropatnick J; Institute of Immunotherapy of Nanchang University, and Jiangxi Academy of Medical Sciences, Nanchang 330006, People's Republic of China.
Min W; Department of Surgery, Western University, London, Canada N6A 5A5.

Open Biol ; 9(10): 190061, 2019 10 31.

Article em En | MEDLINE | ID: mdl-31594465

Assuntos

Linfócitos T CD8-Positivos/metabolismo; Citocinas/metabolismo; Neoplasias Mamárias Experimentais/genética; MicroRNAs/metabolismo; Regiões 3' não Traduzidas; Animais; Linfócitos T CD8-Positivos/imunologia; Linhagem Celular Tumoral; Células Cultivadas; Citocinas/genética; Feminino; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Receptor Celular 2 do Vírus da Hepatite A/genética; Receptor Celular 2 do Vírus da Hepatite A/metabolismo; Imunoterapia/métodos; Neoplasias Mamárias Experimentais/metabolismo; Neoplasias Mamárias Experimentais/terapia; Camundongos; Camundongos Endogâmicos BALB C; MicroRNAs/genética; Receptor de Morte Celular Programada 1/genética; Receptor de Morte Celular Programada 1/metabolismo; Receptores Imunológicos/genética; Receptores Imunológicos/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo

Palavras-chave

PD-1; T-cell exhaustion; breast cancer; immunotherapy; mir-149-3p

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Linfócitos T CD8-Positivos / MicroRNAs / Neoplasias Mamárias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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