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Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort.
Polinski, Kristen J; Bemis, Elizabeth A; Feser, Marie; Seifert, Jennifer; Demoruelle, M Kristen; Striebich, Christopher C; Brake, Stacey; O'Dell, James R; Mikuls, Ted R; Weisman, Michael H; Gregersen, Peter K; Keating, Richard M; Buckner, Jane; Nicassio, Perry; Holers, V Michael; Deane, Kevin D; Norris, Jill M.
Afiliação
  • Polinski KJ; Colorado School of Public Health, Aurora.
  • Bemis EA; Colorado School of Public Health, Aurora.
  • Feser M; University of Colorado School of Medicine, Aurora.
  • Seifert J; Colorado School of Public Health, Aurora.
  • Demoruelle MK; University of Colorado School of Medicine, Aurora.
  • Striebich CC; University of Colorado School of Medicine, Aurora.
  • Brake S; Nine Health Services, Denver, Colorado.
  • O'Dell JR; University of Nebraska Medical Center, Omaha.
  • Mikuls TR; University of Nebraska Medical Center, Omaha.
  • Weisman MH; Cedars-Sinai Medical Center, Los Angeles, California.
  • Gregersen PK; Feinstein Institutes for Medical Research and North Shore-Long Island Jewish Health System, Manhasset, New York.
  • Keating RM; University of Chicago, Chicago, Illinois.
  • Buckner J; Benaroya Research Institute at Virginia Mason, Seattle, Washington.
  • Nicassio P; University of California, Los Angeles.
  • Holers VM; University of Colorado School of Medicine, Aurora.
  • Deane KD; University of Colorado School of Medicine, Aurora.
  • Norris JM; Colorado School of Public Health, Aurora.
Arthritis Care Res (Hoboken) ; 72(12): 1766-1771, 2020 12.
Article em En | MEDLINE | ID: mdl-31600025
ABSTRACT

OBJECTIVE:

The aim of this study was to determine the association of perceived stress with incident inflammatory arthritis (IA) defined as having at least 1 joint consistent with rheumatoid arthritis (RA)-like synovitis based on examination.

METHODS:

We conducted a prospective cohort study in the Studies of the Etiologies of Rheumatoid Arthritis cohort. Participants without IA were recruited if they were a first-degree relative of an RA proband or screened positive for anti-citrullinated protein antibody. Perceived stress was measured using the Perceived Stress Scale-14 (PSS-14), in which scores can range from 0 to 56, and a higher score indicates greater perceived stress. The total PSS-14 score, as well as 2 subscores indicative of perceived distress and self-efficacy, were averaged across all study visits until development of IA or the last follow-up. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) of IA associated with average PSS-14 scores were obtained using Cox proportional hazards models.

RESULTS:

The mean total PSS-14 score was 20.4. We found that a 1-point increase in the perceived distress score was significantly associated with a 10-percent increase in the risk of IA (adjusted HR 1.10 [95% CI 1.02-1.19]). Total PSS-14 and self-efficacy were not associated with IA risk (adjusted HR 1.05 [95% CI 0.99-1.10] and 1.04 [95% CI 0.91-1.18], respectively).

CONCLUSION:

An association between perceived distress and incident IA was observed in this at-risk cohort. Replication of this finding in other preclinical and at-risk RA populations is needed.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Estresse Psicológico Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Estresse Psicológico Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2020 Tipo de documento: Article