Evaluation of Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Glomerular Filtration Rate and Amikacin Clearance During Early Rat Endotoxemia: Comparison with Traditional Endogenous and Exogenous Biomarkers.

Studená, Sárka; Dolezelová, Eva; Cermanová, Jolana; Prasnická, Alena; Springer, Drahomíra; Micuda, Stanislav; Chládek, Jaroslav

Studená, Sárka; Dolezelová, Eva; Cermanová, Jolana; Prasnická, Alena; Springer, Drahomíra; Micuda, Stanislav; Chládek, Jaroslav.

Afiliação

Studená S; Department of Pharmacology, Charles University, Faculty of Medicine Hradec Králové, Simkova 870, 500 38, Hradec Králové, Czech Republic.
Dolezelová E; Department of Biological and Medical Sciences, Charles University, Faculty of Pharmacy, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.
Cermanová J; Department of Pharmacology, Charles University, Faculty of Medicine Hradec Králové, Simkova 870, 500 38, Hradec Králové, Czech Republic.
Prasnická A; Department of Pharmacology, Charles University, Faculty of Medicine Hradec Králové, Simkova 870, 500 38, Hradec Králové, Czech Republic.
Springer D; Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08, Praha 2, Czech Republic.
Micuda S; Department of Pharmacology, Charles University, Faculty of Medicine Hradec Králové, Simkova 870, 500 38, Hradec Králové, Czech Republic.
Chládek J; Department of Pharmacology, Charles University, Faculty of Medicine Hradec Králové, Simkova 870, 500 38, Hradec Králové, Czech Republic. chladekj@lfhk.cuni.cz.

Eur J Drug Metab Pharmacokinet ; 45(1): 71-80, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31605364

Assuntos

Amicacina/farmacocinética; Biomarcadores/sangue; Lipocalina-2/metabolismo; Ratos Wistar; Sepse/metabolismo; Injúria Renal Aguda/sangue; Amicacina/sangue; Amicacina/metabolismo; Animais; Citocinas; Endotoxemia/induzido quimicamente; Taxa de Filtração Glomerular/fisiologia; Inflamação; Rim/fisiopatologia; Lipocalina-2/sangue; Lipocalina-2/urina; Lipopolissacarídeos/farmacologia; Masculino; Taxa de Depuração Metabólica; Modelos Animais; Oligossacarídeos/farmacocinética; Valor Preditivo dos Testes; Ratos; Sepse/tratamento farmacológico; Urina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Amicacina / Biomarcadores / Ratos Wistar / Sepse / Lipocalina-2 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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