Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.

Kumar, Pranesh; Agarwal, Aakriti; Singh, Ashok K; Gautam, Anurag Kumar; Chakraborti, Sreemoyee; Kumar, Umesh; Kumar, Dinesh; Bhattacharya, Bolay; Panda, Parthasarathi; Saha, Biswajit; Qidwai, Tabish; Maity, Biswanath; Saha, Sudipta

Kumar, Pranesh; Agarwal, Aakriti; Singh, Ashok K; Gautam, Anurag Kumar; Chakraborti, Sreemoyee; Kumar, Umesh; Kumar, Dinesh; Bhattacharya, Bolay; Panda, Parthasarathi; Saha, Biswajit; Qidwai, Tabish; Maity, Biswanath; Saha, Sudipta.

Afiliação

Kumar P; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow, 226025, India.
Agarwal A; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow, 226025, India.
Singh AK; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow, 226025, India.
Gautam AK; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow, 226025, India.
Chakraborti S; Centre of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India.
Kumar U; Centre of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India.
Kumar D; Centre of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India.
Bhattacharya B; Gethanjali College of Pharmacy, Cheeryal, Keesara, Hyderabad, 501301, India.
Panda P; Dr. B.C. Roy College of Pharmacy & Allied Health Sciences, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur, 713206, WB, India.
Saha B; Department of Chemical Engineering, National Institute of Technology, Rourkela, Odisha, 769008, India.
Qidwai T; Faculty of Biotechnology, IBST, Shri Ramswaroop Memorial University Lucknow, Deva Road, UP, 225003, India.
Maity B; Centre of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India.
Saha S; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow, 226025, India. Electronic address: sudiptapharm@gmail.com.

Regul Toxicol Pharmacol ; 109: 104489, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31605713

Assuntos

Antineoplásicos/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas Experimentais/tratamento farmacológico; Compostos de Tosil/farmacologia; Animais; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Proteínas Reguladoras de Apoptose/sangue; Proteínas Reguladoras de Apoptose/metabolismo; Carcinoma Hepatocelular/sangue; Carcinoma Hepatocelular/induzido quimicamente; Carcinoma Hepatocelular/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Dietilnitrosamina/toxicidade; Ensaios de Seleção de Medicamentos Antitumorais; Fluoruracila/farmacologia; Fluoruracila/uso terapêutico; Humanos; Indóis; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Neoplasias Hepáticas Experimentais/sangue; Neoplasias Hepáticas Experimentais/induzido quimicamente; Neoplasias Hepáticas Experimentais/metabolismo; Masculino; Metabolômica; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Fenilcarbamatos; Espectroscopia de Prótons por Ressonância Magnética; Ratos; Sulfonamidas; Compostos de Tosil/uso terapêutico

Palavras-chave

(1)H-NMR based metabolomics; Apoptosis; Bcl-2 and BAX proteins; Hepatocellular carcinoma; Zafirlukast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Tosil / Carcinoma Hepatocelular / Neoplasias Hepáticas Experimentais / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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