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The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.
Cresto, Noémie; Gaillard, Marie-Claude; Gardier, Camille; Gubinelli, Francesco; Diguet, Elsa; Bellet, Déborah; Legroux, Laurine; Mitja, Julien; Auregan, Gwenaëlle; Guillermier, Martine; Josephine, Charlène; Jan, Caroline; Dufour, Noëlle; Joliot, Alain; Hantraye, Philippe; Bonvento, Gilles; Déglon, Nicole; Bemelmans, Alexis-Pierre; Cambon, Karine; Liot, Géraldine; Brouillet, Emmanuel.
Afiliação
  • Cresto N; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Gaillard MC; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Gardier C; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Gubinelli F; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Diguet E; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France; Institut de Recherche SERVIER, Neuropsy
  • Bellet D; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Legroux L; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Mitja J; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Auregan G; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Guillermier M; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Josephine C; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Jan C; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Dufour N; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Joliot A; Homeoprotein and Plasticity, Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, PSL Research University, Paris, France.
  • Hantraye P; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Bonvento G; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Déglon N; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; Lausanne University Medical School (CHUV), Department of Clinical Neurosciences (DNC), Laboratory of Cellular and Molecular Neurotherapies (LNCM), Lausanne, Switzerland; La
  • Bemelmans AP; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Cambon K; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Liot G; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France.
  • Brouillet E; CEA, DRF, Institut de Biologie Françoise Jacob, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France; CNRS, CEA, Paris-Sud Univ., Univ. Paris-Saclay, Neurodegenerative Diseases Laboratory (UMR9199), F-92265 Fontenay-aux-Roses, France. Electronic address: emmanuel.brouillet@
Neurobiol Dis ; 134: 104614, 2020 02.
Article em En | MEDLINE | ID: mdl-31605779
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Neurônios Dopaminérgicos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Domínios Proteicos / Degeneração Neural Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Neurônios Dopaminérgicos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Domínios Proteicos / Degeneração Neural Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article