MicroRNA dysregulation in manic and euthymic patients with bipolar disorder.
J Affect Disord
; 261: 84-90, 2020 01 15.
Article
em En
| MEDLINE
| ID: mdl-31605836
ABSTRACT
BACKGROUND:
Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3'- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. SUBJECTS ANDMETHODS:
Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls.RESULTS:
Four microRNAs (miR-29a-3p, pâ¯=â¯0.035; miR-106b-5p, pâ¯=â¯0.014; miR-107, pâ¯=â¯0.011; and miR-125a-3p, pâ¯=â¯0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, pâ¯=â¯0.032; miR-29a-3p, pâ¯=â¯0.001; miR-106a-5p, pâ¯=â¯0.034; miR-106b-5p, pâ¯=â¯0.003; miR-107, pâ¯<â¯0.001; miR-125a-3p, pâ¯=â¯0.016; and miR-125b-5p, pâ¯=â¯0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, pâ¯=â¯0.013, and miR-107, pâ¯=â¯0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients.CONCLUSIONS:
Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Regulação da Expressão Gênica
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Transtorno Ciclotímico
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MicroRNAs
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article