Functional Loss of <i>ATRX</i> and <i>TERC</i> Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells.

Graham, Mindy K; Kim, Jiyoung; Da, Joseph; Brosnan-Cashman, Jacqueline A; Rizzo, Anthony; Baena Del Valle, Javier A; Chia, Lionel; Rubenstein, Michael; Davis, Christine; Zheng, Qizhi; Cope, Leslie; Considine, Michael; Haffner, Michael C; De Marzo, Angelo M; Meeker, Alan K; Heaphy, Christopher M

Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells.

Graham, Mindy K; Kim, Jiyoung; Da, Joseph; Brosnan-Cashman, Jacqueline A; Rizzo, Anthony; Baena Del Valle, Javier A; Chia, Lionel; Rubenstein, Michael; Davis, Christine; Zheng, Qizhi; Cope, Leslie; Considine, Michael; Haffner, Michael C; De Marzo, Angelo M; Meeker, Alan K; Heaphy, Christopher M.

Afiliação

Graham MK; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kim J; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Da J; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Brosnan-Cashman JA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rizzo A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Baena Del Valle JA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chia L; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rubenstein M; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland.
Davis C; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Zheng Q; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Cope L; Department of Oncology Johns Hopkins University School of Medicine, Baltimore, Maryland.
Considine M; Department of Oncology Johns Hopkins University School of Medicine, Baltimore, Maryland.
Haffner MC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
De Marzo AM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Meeker AK; Department of Oncology Johns Hopkins University School of Medicine, Baltimore, Maryland.
Heaphy CM; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Mol Cancer Res ; 17(12): 2480-2491, 2019 12.

Article em En | MEDLINE | ID: mdl-31611308

Assuntos

Neoplasias da Próstata/genética; RNA/genética; Telomerase/genética; Homeostase do Telômero/genética; Proteína Nuclear Ligada ao X/genética; Sistemas CRISPR-Cas/genética; Linhagem Celular Tumoral; Montagem e Desmontagem da Cromatina/genética; Instabilidade Cromossômica/genética; Regulação Neoplásica da Expressão Gênica/genética; Técnicas de Inativação de Genes; Humanos; Masculino; Mutação; Próstata/metabolismo; Próstata/patologia; Neoplasias da Próstata/patologia; Telômero/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / RNA / Telomerase / Homeostase do Telômero / Proteína Nuclear Ligada ao X Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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