The Use of Microfluidic Neuronal Devices to Study the Anterograde Axonal Transport of Herpes Simplex Virus-1.
Methods Mol Biol
; 2060: 409-418, 2020.
Article
em En
| MEDLINE
| ID: mdl-31617194
ABSTRACT
Understanding how herpes simplex virus-1 (HSV-1) interacts with different parts of the neuron is fundamental in understanding the mechanisms behind HSV-1 transport during primary and recurrent infections. In this chapter, we describe a unique neuronal culture system that is capable of compartmentalizing neuronal cell bodies from their axons to study the transport of HSV-1 along axons. The ability to separate neuronal cell bodies and axons provides a unique model to investigate the mechanisms used by HSV-1 for viral transport, assembly, and exit from different parts of the neuron.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
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Transporte Axonal
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Herpesvirus Humano 1
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Técnicas Analíticas Microfluídicas
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Dispositivos Lab-On-A-Chip
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Gânglios Espinais
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article