Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos.
Nat Prod Res
; 35(14): 2295-2302, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-31617416
ABSTRACT
Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone were isolated from the agarwood of Aquilaria crassna Pierre ex Lecomte in Laos. The structures of the isolates were elucidated by spectroscopic methods, and their configurations were determined via ROESY correlations, 3 J H-H coupling constants analyses, comparisons of chemical shifts and specific rotations with known compounds, and ECD calculation in the case of 1. Compounds 1-4 were evaluated for their cytotoxicity. Compounds 1 and 2 exhibited weak cytotoxicity toward HeLa cell line (IC50 49.8 ± 1.2 µM) and K562 cell line (IC50 42.66 ± 0.47 µM), respectively.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Madeira
/
Flavonoides
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Thymelaeaceae
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article