Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.

Emperle, Max; Adam, Sabrina; Kunert, Stefan; Dukatz, Michael; Baude, Annika; Plass, Christoph; Rathert, Philipp; Bashtrykov, Pavel; Jeltsch, Albert

Emperle, Max; Adam, Sabrina; Kunert, Stefan; Dukatz, Michael; Baude, Annika; Plass, Christoph; Rathert, Philipp; Bashtrykov, Pavel; Jeltsch, Albert.

Afiliação

Emperle M; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Adam S; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Kunert S; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Dukatz M; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Baude A; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 28069120 Heidelberg, Germany.
Plass C; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 28069120 Heidelberg, Germany.
Rathert P; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Bashtrykov P; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Jeltsch A; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.

Nucleic Acids Res ; 47(21): 11355-11367, 2019 12 02.

Article em En | MEDLINE | ID: mdl-31620784

Assuntos

Região 5'-Flanqueadora/genética; DNA (Citosina-5-)-Metiltransferases/genética; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA/genética; Mutação de Sentido Incorreto; Substituição de Aminoácidos; Arginina/genética; Sítios de Ligação/genética; Domínio Catalítico; Ilhas de CpG/genética; DNA (Citosina-5-)-Metiltransferases/química; DNA Metiltransferase 3A; Células HCT116; Histidina/genética; Humanos; Neoplasias/genética; Neoplasias/metabolismo; Especificidade por Substrato/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Mutação de Sentido Incorreto / Região 5'-Flanqueadora / DNA (Citosina-5-)-Metiltransferases Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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