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Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.
Ge, Mao-Xu; Liu, Hong-Tao; Zhang, Na; Niu, Wei-Xiao; Lu, Zhen-Ning; Bao, Yun-Yang; Huang, Rui; Yu, Dong-Ke; Shao, Rong-Guang; He, Hong-Wei.
Afiliação
  • Ge MX; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Liu HT; Department of Pharmacy, Hebei General Hospital, Shijiazhuang, China.
  • Zhang N; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Niu WX; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Lu ZN; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Bao YY; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Huang R; Department of digestive surgery, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China.
  • Yu DK; Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China.
  • Shao RG; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • He HW; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Br J Pharmacol ; 177(2): 372-387, 2020 01.
Article em En | MEDLINE | ID: mdl-31621893
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ubiquitina-Proteína Ligases / Células Estreladas do Fígado / Receptor Notch3 / Fígado / Cirrose Hepática Experimental Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ubiquitina-Proteína Ligases / Células Estreladas do Fígado / Receptor Notch3 / Fígado / Cirrose Hepática Experimental Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article