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The Potassium Channel Kv1.5 Expression Alters During Experimental Autoimmune Encephalomyelitis.
Bozic, I; Savic, D; Milosevic, A; Janjic, M; Laketa, D; Tesovic, K; Bjelobaba, I; Jakovljevic, M; Nedeljkovic, N; Pekovic, S; Lavrnja, I.
Afiliação
  • Bozic I; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Savic D; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Milosevic A; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Janjic M; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Laketa D; Department for General Physiology and Biophysics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
  • Tesovic K; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Bjelobaba I; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Jakovljevic M; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Nedeljkovic N; Department for General Physiology and Biophysics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
  • Pekovic S; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Lavrnja I; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. irenam@ibiss.bg.ac.rs.
Neurochem Res ; 44(12): 2733-2745, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31624998
Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative disease with an autoimmune component. It was suggested that potassium channels, which are involved in crucial biological functions may have a role in different diseases, including MS and its animal model, experimental autoimmune encephalomyelitis (EAE). It was shown that voltage-gated potassium channels Kv1.5 are responsible for fine-tuning in the immune physiology and influence proliferation and differentiation in microglia and astrocytes. Here, we explored the cellular distribution of the Kv1.5 channel, together with its transcript and protein expression in the male rat spinal cord during different stages of EAE. Our results reveal a decrease of Kv1.5 transcript and protein level at the peak of disease, where massive infiltration of myeloid cells occurs, together with reactive astrogliosis and demyelination. Also, we revealed that the presence of this channel is not found in infiltrating macrophages/microglia during EAE. It is interesting to note that Kv1.5 channel is expressed only in resting microglia in the naïve animals. Predominant expression of Kv1.5 channel was found in the astrocytes in all experimental groups, while some vimentin+ cells, resembling macrophages, are devoid of Kv1.5 expression. Our results point to the possible link between Kv1.5 channel and the pathophysiological processes in EAE.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Canal de Potássio Kv1.5 Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Canal de Potássio Kv1.5 Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article