A Rare Morphology Resembling APL with t (11;12) (p15;q13) in Acute Myeloid Leukemia: Case Report and Literature Review.
Clin Lab
; 65(10)2019 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-31625367
ABSTRACT
BACKGROUND:
To investigate the clinical features of and therapeutic options for a rare morphology resembling APL with t (11;12) (p15;q13) in acute myeloid leukemia.METHODS:
One case of APL-like acute leukemia with a t (11;12) (p15;q13) translocation is reported and related literature is retrospectively reviewed.RESULTS:
A rare acute myeloid leukemia with a t (11;12) (p15;q13) translocation was diagnosed by morphology, immunophenotyping, chromosome analysis, and fusion gene detection, without finding a classical t (15;17) (q24.1;q21.1) translocation and the PML-RARa fusion gene. The patient responded poorly to differentiation induction therapy with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). In the three previous cases re-ported, poor results were obtained with ATRA and/or ATO therapy.CONCLUSIONS:
We reported a rare meaningful AML patient with t (11;12) (p15;q13). Standard AML regimens may be preferred. These APL-like leukemias may benefit from hematopoietic stem cell transplantation treatment. Further investigation involving more cases is needed to determine the role of t (11;12) (p15;q13) in AML and to find better therapy choices.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Leucemia Mieloide
/
Proteínas de Fusão Oncogênica
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article