Design and rationale of the atrial fibrillation occurring transiently with stress (AFOTS) incidence study.
J Electrocardiol
; 57: 95-99, 2019.
Article
em En
| MEDLINE
| ID: mdl-31629099
ABSTRACT
BACKGROUND:
Atrial fibrillation (AF) is often detected for the first time in patients hospitalized for medical illness or non-cardiovascular surgery. AF occurring transiently with stress (AFOTS) describes this manifestation of AF, which may either be the result of a non-cardiac stressor, or existing paroxysmal AF that was not previously detected. Current estimates of AFOTS incidence are imprecise ranging from 1 to 44%, owing to the marked heterogeneity in patient populations, identification and methods used to detect AFOTS.METHODS:
The prospective, two-centre epidemiological AFOTS Incidence study will enroll 250 consecutive participants without a history of AF but with at increased risk of AF (Ageâ¯≥â¯65 or >50 with one risk factor for AF) admitted to intensive care units (ICUs) for medical illness or non-cardiac surgery. Upon admission, participants will wear an ECG patch monitor that will remain in place for 14â¯days, or until discharge from hospital. Patients' consent to participation is deferred for up to 72â¯h after admission. The primary endpoint is the incidence of AF lasting ≥30â¯s. The study is powered to detect an AF incidence of 17%⯱â¯5%.RESULTS:
We conducted a vanguard feasibility study, and 55 participants have completed participation. The median duration of monitoring was seven days. AF was detected by the clinical team in 8 participants (14%; 95% Confidence Interval 7-26%).CONCLUSIONS:
The AFOTS Incidence study will employ a systematic and highly sensitive protocol for detecting AFOTS in medical illness and non-cardiac surgery ICU patients. This study is feasible and will provide a reliable estimate of the true incidence of AFOTS in this population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article