During infant maltreatment, stress targets hippocampus, but stress with mother present targets amygdala and social behavior.
Proc Natl Acad Sci U S A
; 116(45): 22821-22832, 2019 11 05.
Article
em En
| MEDLINE
| ID: mdl-31636210
ABSTRACT
Infant maltreatment increases vulnerability to physical and mental disorders, yet specific mechanisms embedded within this complex infant experience that induce this vulnerability remain elusive. To define critical features of maltreatment-induced vulnerability, rat pups were reared from postnatal day 8 (PN8) with a maltreating mother, which produced amygdala and hippocampal deficits and decreased social behavior at PN13. Next, we deconstructed the maltreatment experience to reveal sufficient and necessary conditions to induce this phenotype. Social behavior and amygdala deficits (volume, neurogenesis, c-Fos, local field potential) required combined chronic high corticosterone and maternal presence (not maternal behavior). Hippocampal deficits were induced by chronic high corticosterone regardless of social context. Causation was shown by blocking corticosterone during maltreatment and suppressing amygdala activity during social behavior testing. These results highlight (1) that early life maltreatment initiates multiple pathways to pathology, each with distinct causal mechanisms and outcomes, and (2) the importance of social presence on brain development.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
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Estresse Fisiológico
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Hipocampo
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Tonsila do Cerebelo
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Mães
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article