An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies.
Molecules
; 24(20)2019 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-31640154
ABSTRACT
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3-7 membered rings.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Éteres Cíclicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article