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Molecular Biology and Evolution of Cancer: From Discovery to Action.
Somarelli, Jason A; Gardner, Heather; Cannataro, Vincent L; Gunady, Ella F; Boddy, Amy M; Johnson, Norman A; Fisk, Jeffrey Nicholas; Gaffney, Stephen G; Chuang, Jeffrey H; Li, Sheng; Ciccarelli, Francesca D; Panchenko, Anna R; Megquier, Kate; Kumar, Sudhir; Dornburg, Alex; DeGregori, James; Townsend, Jeffrey P.
Afiliação
  • Somarelli JA; Department of Medicine, Duke University Medical Center, Durham, NC.
  • Gardner H; Duke Cancer Institute, Duke University Medical Center, Durham, NC.
  • Cannataro VL; Sackler School of Graduate Biomedical Sciences, Tufts University, Medford, MA.
  • Gunady EF; Department of Biology, Emmanuel College, Boston, MA.
  • Boddy AM; Department of Medicine, Duke University Medical Center, Durham, NC.
  • Johnson NA; Department of Anthropology, University of California, Santa Barbara, CA.
  • Fisk JN; Department of Biology, University of Massachusetts, Amherst, MA.
  • Gaffney SG; Department of Biostatistics, Yale School of Public Health, New Haven, CT.
  • Chuang JH; Department of Biostatistics, Yale School of Public Health, New Haven, CT.
  • Li S; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Ciccarelli FD; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Panchenko AR; Cancer Systems Biology Laboratory, The Francis Crick Institute, London, United Kingdom.
  • Megquier K; King's College London, London, United Kingdom.
  • Kumar S; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada.
  • Dornburg A; Ontario Institute of Cancer Research, Toronto, ON, Canada.
  • DeGregori J; Broad Institute, Massachusettes Institute of Technology and Harvard University.
  • Townsend JP; Institute for Genomics and Evolutionary Medicine, and Department of Biology, Temple University, Philadelphia, PA.
Mol Biol Evol ; 37(2): 320-326, 2020 02 01.
Article em En | MEDLINE | ID: mdl-31642480
ABSTRACT
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genômica / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genômica / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article