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Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing.
Broadwater, Deanna; Bates, Matthew; Jayaram, Mayank; Young, Margaret; He, Jianzhou; Raithel, Austin L; Hamann, Thomas W; Zhang, Wei; Borhan, Babak; Lunt, Richard R; Lunt, Sophia Y.
Afiliação
  • Broadwater D; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
  • Bates M; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
  • Jayaram M; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
  • Young M; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
  • He J; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, USA.
  • Raithel AL; Department of Chemistry, Michigan State University, East Lansing, MI, USA.
  • Hamann TW; Department of Chemistry, Michigan State University, East Lansing, MI, USA.
  • Zhang W; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, USA.
  • Borhan B; Environmental Science and Policy Program, Michigan State University, East Lansing, MI, USA.
  • Lunt RR; Department of Chemistry, Michigan State University, East Lansing, MI, USA.
  • Lunt SY; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA. rlunt@msu.edu.
Sci Rep ; 9(1): 15288, 2019 10 25.
Article em En | MEDLINE | ID: mdl-31653966
Light-activated theranostics offer promising opportunities for disease diagnosis, image-guided surgery, and site-specific personalized therapy. However, current fluorescent dyes are limited by low brightness, high cytotoxicity, poor tissue penetration, and unwanted side effects. To overcome these limitations, we demonstrate a platform for optoelectronic tuning, which allows independent control of the optical properties from the electronic properties of fluorescent organic salts. This is achieved through cation-anion pairing of organic salts that can modulate the frontier molecular orbital without impacting the bandgap. Optoelectronic tuning enables decoupled control over the cytotoxicity and phototoxicity of fluorescent organic salts by selective generation of mitochondrial reactive oxygen species that control cell viability. We show that through counterion pairing, organic salt nanoparticles can be tuned to be either nontoxic for enhanced imaging, or phototoxic for improved photodynamic therapy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Orgânicos / Sais / Fármacos Fotossensibilizantes / Corantes Fluorescentes Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Orgânicos / Sais / Fármacos Fotossensibilizantes / Corantes Fluorescentes Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article