Construction and Characterization of a Mirror-Image l-DNA i-Motif.

Sun, Yawei; Yang, Bo; Hua, Yi; Dong, Yuanchen; Ye, Jianhan; Wang, Jiqian; Xu, Lijin; Liu, Dongsheng

Sun, Yawei; Yang, Bo; Hua, Yi; Dong, Yuanchen; Ye, Jianhan; Wang, Jiqian; Xu, Lijin; Liu, Dongsheng.

Afiliação

Sun Y; State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (Huadong), Qingdao, 266580, P. R. China.
Yang B; Key Lab of Organic Optoelectronics and, Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Hua Y; Key Lab of Organic Optoelectronics and, Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Dong Y; CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Science, Beijing, 100084, P. R. China.
Ye J; CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Science, Beijing, 100084, P. R. China.
Wang J; State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (Huadong), Qingdao, 266580, P. R. China.
Xu L; Department of Chemistry, Renmin University, Beijing, 100084, P. R. China.
Liu D; Key Lab of Organic Optoelectronics and, Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

Chembiochem ; 21(1-2): 94-97, 2020 01 15.

Article em En | MEDLINE | ID: mdl-31659823

ABSTRACT

ABSTRACT

The first thermally stable and pH-responsive quadruplex intercalated motif (i-motif) structure formed by l-DNA is presented. Although this l-type i-motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest.

Assuntos

DNA/química; Concentração de Íons de Hidrogênio; Conformação de Ácido Nucleico; Motivos de Nucleotídeos; Termodinâmica

Palavras-chave

DNA structures; chirality; i-motifs; l-DNA; self-assembly

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